Creatine

Creatine Monohydrate

Creatine is a naturally occurring compound found in small amounts in meat and fish and synthesised in the body from amino acids. It plays a key role in cellular energy production, particularly in tissues with high energy demand such as muscle and brain. It is one of the most extensively studied nutritional compounds, with strong evidence supporting its role in physical performance, muscle health, and cognitive function. Creatine is also widely supported by leaders in longevity, sports science, and clinical nutrition due to its consistent evidence base and safety profile.

Creatine is among the most well-researched compounds in nutrition science, with hundreds of studies including randomized controlled trials and meta-analyses supporting its efficacy and safety. It is consistently recommended across disciplines including performance science, healthy ageing, and cognitive health.

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Nutrient Profile

- Creatine
- Phosphocreatine

Why We Include It

Physical performance and strength Creatine consistently improves high-intensity exercise performance, strength, and power output.

Muscle mass and healthy ageing Creatine supports muscle mass and function, particularly when combined with resistance training.

Brain energy and cognition Creatine plays a role in brain energy metabolism and may support cognitive performance.

Recovery and cellular energy Creatine enhances cellular ATP availability, supporting recovery and resilience.

The Evidence

Physical Performance

Position stand / systematic review

Improves strength, power, and exercise performance.

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Muscle Mass and Ageing

Systematic review and meta-analysis

Increased lean mass and strength with creatine.

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Cognitive Function

Randomised controlled trial

Improved working memory and cognitive performance.

View study on PubMed →

Summary

Creatine is one of the most well-supported compounds in nutrition science, with strong evidence for improving physical performance, supporting muscle mass, and contributing to cognitive function. It is widely supported by experts across longevity, performance, and clinical nutrition fields.

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