Lion’s Mane

Hericium erinaceus

Lion’s Mane is a medicinal mushroom that has been used in traditional Chinese and Japanese medicine for centuries. In recent years, it has gained significant scientific attention for its potential effects on brain health, cognition, and nerve regeneration.

Unlike many plant compounds, Lion’s Mane contains unique bioactive molecules (hericenones and erinacines) that are able to stimulate Nerve Growth Factor (NGF), a protein essential for the growth, maintenance, and survival of neurons.

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Nutrient Profile

Lion’s Mane contains a range of biologically active compounds:
- Hericenones and erinacines — associated with NGF stimulation  
- Polysaccharides — supporting immune and metabolic health  
- Antioxidants — reducing oxidative stress
- Beta-glucans — contributing to immune modulation

These compounds underpin Lion’s Mane’s neurological and systemic effects.

Why We Include It

Lion’s Mane is included for its potential role in supporting cognitive function, memory, and long-term brain health.

NGF plays a central role in neuroplasticity and neuronal repair. By stimulating NGF production, Lion’s Mane may support the maintenance and regeneration of neurons, which is particularly relevant for ageing populations.

From a longevity perspective, preserving cognitive function is one of the most important determinants of quality of life, making Lion’s Mane a key ingredient within a brain-supportive nutritional strategy.

The Evidence

Cognitive Function in Mild Cognitive Impairment

Randomised, double-blind, placebo-controlled trial

Participants receiving Lion’s Mane showed significant improvements in cognitive function compared with placebo.

View study on PubMed →

Mood and Anxiety

Randomised, placebo-controlled trial

Lion’s Mane supplementation was associated with improvements in mood and reductions in anxiety symptoms.

View study on PubMed →

Summary

Lion’s Mane is one of the most promising natural compounds for supporting brain health, with both human clinical evidence and well-established biological mechanisms. Its ability to stimulate NGF and support cognitive function makes it a cornerstone ingredient in a longevity-focused formulation aimed at preserving mental performance and neurological health.

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